Effects of Flibanserin on Subdomain Scores of the Female Sexual Function Index in Women With Hypoactive Sexual Desire Disorder

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Effects of Flibanserin on Subdomain Scores of the Female Sexual Function Index in Women With Hypoactive Sexual Desire DisorderIntroduction: Flibanserin treatment increases sexual desire and satisfying sexual events while decreasing distress in certain women diagnosed with acquired, generalized hypoactive sexual desire disorder (HSDD). Additional aspects of sexual function and the time course of response have…

Flibanserin for premenopausal hypoactive sexual desire disorder: Pooled analysis of clinical trials

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Flibanserin for premenopausal hypoactive sexual desire disorder: Pooled analysis of clinical trialsBackground: Flibanserin, a 5-hydroxytryptamine 5-HT 1A  agonist and 5-HT 2A  antagonist, is indicated for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This post hoc analysis assessed pooled efficacy and safety data for flibanserin in premenopausal women with HSDD.…

Effects of alcohol administered with flibanserin in healthy premenopausal women: A randomized, double-blind, single-dose crossover study

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Effects of alcohol administered with flibanserin in healthy premenopausal women: A randomized, double-blind, single-dose crossover studyIntroduction: Flibanserin is approved in the United States and Canada for the treatment of hypoactive sexual desire disorder in premenopausal women. Aim: The purpose of this trial was to evaluate the safety of concomitant administration of flibanserin with alcohol. Methods:…

Safety and tolerability of evening ethanol consumption and bedtime administration of flibanserin in healthy premenopausal female subjects

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Safety and tolerability of evening ethanol consumption and bedtime administration of flibanserin in healthy premenopausal female subjectsIntroduction: Flibanserin, a treatment for hypoactive sexual desire disorder, carries warnings for increased risk of severe hypotension and syncope when used with alcohol. However, these warnings are not informed by studies that used flibanserin’s recommended bedtime dosing because previous…

Effects of timing of flibanserin administration relative to alcohol intake in healthy premenopausal women: A randomized, double-blind, crossover study

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Effects of timing of flibanserin administration relative to alcohol intake in healthy premenopausal women: A randomized, double-blind, crossover studyIntroduction: Flibanserin is approved in the United States and Canada for the treatment of acquired, generalized, hypoactive sexual desire disorder in premenopausal women. Sedation-related side effects are among the most prevalent adverse events. Although infrequent, hypotension and…